Protocol Library

Design, Analyze, Communicate: Working together to improve clinical study outcomes.

Human Immunodeficiency Virus

A Mobile Phone Game to Prevent HIV among Young Africans

A Study of the HIV Prevention Trials Network

Sustainable East Africa Research in Community Health (SEARCH)

A 96-week Randomised, Phase 3 Non-inferiority Study of DTG + TAF + FTC Compared with DTG + TDF + FTC and EFV + TDF + FTC in Patients Infected with HIV-1 Starting First-line Antiretroviral Therapy

A multi-centre, randomised, double-blind, placebo-controlled phase ii long-term safety trial of a dapivirine vaginal matrix ring in healthy hiv-negative women

Itraconazole versus Amphotericin B for the Treatment of Penicilliosis

A randomised controlled trial of oral fluconazole plus flucytosine versus amphotericin B-based therapy, for one or two weeks, for initial treatment of HIV-associated cryptococcal meningitis

HIV-1 Prevalence, Incidence, Cohort Retention, and Host Genetics and Viral Diversity in Cohorts in East Africa and Thailand

Same-day antiretroviral therapy versus clinic referral and pre-ART counselling during home-based HIV testing in rural Lesotho (CASCADE trial): An open-label randomized controlled trial


Neglected Tropical Diseases 

Yaws elimination on Lihir Island, New Ireland Province, PNG: A proof of principle of Mass Drug Treatment with azithromycin

A randomized double-blind placebo-controlled trial of benznidazole in patients with chronic Chagas’ heart disease

Efficacy and safety of a single dose regimen and a multi-dose regimen of mebendazole against hookworm infections in children: a randomized controlled trial

A Phase II, double-blind, controlled trial to assess the Safety and Immunogenicity of different schedules of Takeda’s Tetravalent Dengue Vaccine Candidate (TDV) in healthy subjects aged between 2 and <18 years and living in dengue endemic countries in Asi

Community Based Safety Study of 2-drug (Diethylcarbamazine and Albendazole) versus 3-drug (Ivermectin, Diethylcarbamazine and Albendazole) Therapy for Lymphatic Filariasis in Haiti

Community Based Safety and Efficacy Study of 2-drug (Diethylcarbamazine and Albendazole) versus 3-drug (Ivermectin, Diethylcarbamazine and Albendazole) Therapy for Lymphatic Filariasis in Indonesia

Community Based Safety Study of 2-drug (Diethylcarbamazine and Albendazole) versus 3-drug (Ivermectin, Diethylcarbamazine and Albendazole) Therapy for Lymphatic Filariasis in Papua New Guinea



A phase IIb, double-blind, randomised, placebocontrolled study to evaluate the efficacy, safety, and immunogenicity of GSK Biologicals’ candidate tuberculosis (TB) vaccine GSK

A Phase I/IIa Double-Blind, Randomized, Placebo-Controlled, Dose-Finding Study to Evaluate the Safety and Immunogenicity of AERAS-456 in HIV-negative Adults with and without Latent Tuberculosis Infection


ANRS 12136 Temprano

A Randomized controlled trial of community-based screening for tuberculosis (the ACT 3 studies)

Pred-ART trial

A Phase 2 Open‐Label Partially Randomized Trial to Evaluate the Efficacy, Safety and Tolerability of combinations of bedaquiline, moxifloxacin, PA‐824 and pyrazinamide during 8 weeks of treatment in Adult Subjects with Newly Diagnosed Drug‐Sensitive or Multi Drug‐Resistant, Smear‐Positive Pulmonary Tuberculosis.

A Randomized, Placebo Controlled, Partially Blinded Phase II Study to Evaluate Safety, Immunogenicity, and Prevention of Infection with Mycobacterium tuberculosis of AERAS-404 and BCG Revaccination in Healthy Adolescents

A Phase 1b, Randomized, Double-blind, Placebo-controlled, Dose-escalation Study to Evaluate the Safety and Immunogenicity of the ID93 + GLA-SE Vaccine in BCG-Vaccinated Healthy Adults



Extension to study MALARIA-055 PRI (110021) for evaluation of long-term efficacy, safety and immunogenicity of GSK Biologicals’candidate malaria vaccine (SB257049) in infants and children in Africa

STOPMIP Indonesia

Tafenoquine vs. Primaquine to prevent relapse in Plasmodium vivax Malaria

Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and Infants

Phase 1 and 2a Clinical Trial: Immunization of human volunteers with P. vivax irradiated sporozoites

Repeat ivermectin mass drug administrations for control of malaria: a pilot safety and efficacy study


Maternal, Newborn, & Child Health 


Prenatal Iron Supplements: Safety & Efficacy in Tanzania

Impact of Cryotherapy versus Loop  Electrosurgical Excision Procedure (LEEP)  on Recurrence of Cervical Intraepithelial  Neoplasia and HIV-1 Cervical Shedding  among HIV-positive Women

Randomized placebo-controlled trial of maternal vitamin D supplementation during pregnancy and lactation to improve infant linear growth in Dhaka, Bangladesh

Electricity-free Infant Warmer for Newborn Thermoregulation



Sanitation Hygiene Infant Nutrition Efficacy Project




Group B streptococcus vaccination in pregnant women with or without HIV in Africa: a non-randomised phase 2, open-label, multicentre trial

Pivotal study to evaluate the immunogenicity and safety of a measles vaccine given by aerosolized inhalation: randomized controlled trial

A Randomized, Double-blind, Placebo-controlled Study evaluating the safety, tolerability, and immunogenicity of an oral inactivated ETEC Vaccine (ETVAX) alone and together with dmLT adjuvant in descending age groups in Bangladesh

A Post-marketing, Observational, Retrospective Study to Assess the Safety of RefortrixTM (Tdap) When Administered During Pregnancy in a Maternal Immunization Program in Brazil.

A Phase 1 Randomized, Double-Blinded, Placebo-controlled, Dose-Escalation Study to Assess the Safety, Tolerability and Immunogenicity of Live Attenuated, Oral Shigella WRSS1 Vaccine in Bangladeshi Toddlers


Enteric & Diarrheal Diseases

Randomized, double-blind, placebo-controlled phase III clinical trial to assess the efficacy and safety of a pentavalent rotavirus vaccine (BRV-PV) against severe rotavirus gastroenteritis among infants in Niger

An individually randomized, placebo-controlled trial to measure the protection conferred by a single dose regimen of bivalent, killed, whole cell oral cholera vaccine (Shanchol™) in Dhaka, Bangladesh

Assessing the impact of a Vi-Polysaccharide Conjugate Vaccine in preventing typhoid infections among Nepalese children – a Phase III trial



Mortality Reduction After Oral Azithromycin

A Phase 3, Randomized, Double-Blind, Double-Dummy Study to Compare the Efficacy and Safety of Oral Lefamulin (BC-3781) Versus Oral Moxifloxacin in Adults With Community-Acquired Bacterial Pneumonia



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