Clinical studies are the key source of knowledge in the field of global health. However, for a variety of reasons, some studies end without informative results, meaning that the time and effort that went into them did not improve or save lives.

The DAC Trials hub hosts tools and resources, funded by the DAC team at the Bill & Melinda Gates Foundation, intended to optimize the informativeness and impact of global health clinical research. DAC includes an evidence-based catalogue of best practices, assessments, open-source simulation software, and other tools for researchers. Since these approaches and tools can benefit not only Gates Foundation grantees but the broader global health clinical research community, the Global Health Network helped the Gates Foundation launch a publicly available version, the DAC Trials Knowledge Hub.

DAC principles, such as Best Practices for Study Informativeness, are translatable across clinical trials and studies as well as implementation research.

To explore the Hub, click on the buttons or links below to enter each area or focused area, respectively, or navigate using the drop-down menus in the bar above.

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Find out more about the Design, Analyze and Communicate (DAC) Program. What is it and why is it needed?
Find answers to the questions most frequently asked about DAC Frequently Asked Questions and access key publications.
Learn about the DAC Process and associated tools.
DAC Tools and resources
Access the DAC Best Practices; robust clinical study methods, for design, analysis, and communication.
Apply DAC Tools to your study including: the DAC Assessment Tool and Mediana’s Clinical Trial Simulation tool.
Created with Raphaël 2.1.2
Created with Raphaël 2.1.2
Created with Raphaël 2.1.2
Created with Raphaël 2.1.2

Please note: Implementors of studies should also always refer to relevant regulatory standards and guidelines (e.g. FDA, EMA) to assist with study/protocol design.