Clinical Trial Protocol Registry and Library
Design, Analyze, Communicate: Working together to improve clinical study outcomes.
Focusing on research Protocols where the trial sites were located in low- and middle-income countries, this resource includes three ways to access the Protocol Library:
- A table of all of the clinical trial protocols included in the Protocol Library
- A downloadable Excel registry list of all the clinical trial protocols included in the Protocol Library
- The Protocol Library sorted into disease area folders to allow direct access to relevant protocols
Clinical Trial Protocol Registry Table
Use this table to filter the Protocol Library to access specific protocols.
Filter the resources using the dropdown menus. Select a column heading to sort. Click or tap on a row to view the full record
| First Principal Investigator | Protocol Title | Disease/Disease Area | Region of Study |
| Keiser, Jennifer |
Efficacy and safety of a single dose regimen and a multi
dose regimen of mebendazole against hookworm infections in children: a randomized controlled trialLink to ProtocolFirst Principal InvestigatorKeiser, Jennifer Disease/Disease AreaHookworm Site CountriesTanzania Source of Protocolclinicaltrials.gov Approximate Page Count51 Date of Scientific Journal Publication7/1/2018 Scientific Journal Publicationhttps://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(18)30005-1/fulltext |
Hookworm | Africa |
| Sáez Llorens, Xavier |
A Phase II, double-blind, controlled trial to assess the Safety and Immunogenicity of different schedules of Takeda’s Tetravalent Dengue Vaccine Candidate (TDV) in healthy subjects aged between 2 and <18 years and living in dengue endemic countries in Asia and Latin America First Principal InvestigatorSáez Llorens, Xavier Disease/Disease AreaDengue Site CountriesDominican Republic, Panama, Philippines Source of Protocolclinicaltrials.gov Approximate Page Count84 Date of Scientific Journal Publication6/1/2017 Scientific Journal Publicationhttps://pubmed.ncbi.nlm.nih.gov/28365225/ |
Dengue | Multi |
| Divala, Titus |
A Randomized, Controlled Clinical Trial of Chloroquine as Chemoprophylaxis Versus
Intermittent Preventive Therapy to Prevent Malaria in Pregnancy in Malawi First Principal InvestigatorDivala, Titus Disease/Disease AreaMalaria Site CountriesMalawi Source of ProtocolPI Email Approximate Page Count72 Date of Scientific Journal Publication9/4/2018 Scientific Journal Publicationhttps://europepmc.org/article/pmc/pmc6217965 |
Malaria | Africa |
| Grassly, Nicholas |
Treatment of enteric infections among Indian infants to
improve their response to oral poliovirus vaccineLink to ProtocolFirst Principal InvestigatorGrassly, Nicholas Disease/Disease AreaPolio Sub AreaEDD Site CountriesIndia Source of ProtocolPI Email Approximate Page Count60 Date of Scientific Journal Publication5/4/2016 Scientific Journal Publicationhttps://www.thelancet.com/journals/laninf/article/PIIS1473-3099(16)30023-8/fulltext |
Polio | Asia |
| O'Ryan, Miguel |
A Phase 4, Randomized, Open-Label Study to Assess the Induction of Humoral and Intestinal Polio Immunity Following a Three-Dose Trivalent Inactivated Polio Vaccine (IPV) Schedule Relative to Two Sequential Schedules of IPV followed by Bivalent Oral Polio Vaccines (bOPV) Administered during the First Year of LifeLink to ProtocolFirst Principal InvestigatorO'Ryan, Miguel Disease/Disease AreaPolio Site CountriesChile Source of ProtocolPI Email Approximate Page Count95 Date of Scientific Journal Publication10/30/2018 Scientific Journal Publicationhttps://pubmed.ncbi.nlm.nih.gov/30376086/ |
Polio | South America |
| Weil, Gary |
Community Based Safety Study of 2-drug (Diethylcarbamazine and Albendazole) versus 3-drug (Ivermectin, Diethylcarbamazine and Albendazole) Therapy for Lymphatic Filariasis in HaitiLink to ProtocolFirst Principal InvestigatorWeil, Gary Disease/Disease AreaFilariasis Site CountriesHaiti Source of Protocolclinicaltrials.gov Approximate Page Count67 Date of Scientific Journal Publication6/24/2019 Scientific Journal Publicationhttps://pubmed.ncbi.nlm.nih.gov/31233507/ |
Filariasis | North America |
| Weil, Gary |
Community Based Safety and Efficacy Study of 2-drug (Diethylcarbamazine and Albendazole) versus 3-drug (Ivermectin, Diethylcarbamazine and Albendazole) Therapy for Lymphatic Filariasis in IndonesiaLink to ProtocolFirst Principal InvestigatorWeil, Gary Disease/Disease AreaFilariasis Site CountriesIndonesia Source of Protocolclinicaltrials.gov Approximate Page Count108 Date of Scientific Journal Publication6/25/2019 Scientific Journal Publicationhttps://pubmed.ncbi.nlm.nih.gov/31233507/ |
Filariasis | Asia |
| Weil, Gary |
Community Based Safety Study of 2-drug (Diethylcarbamazine and Albendazole) versus 3-drug (Ivermectin, Diethylcarbamazine and Albendazole) Therapy for Lymphatic Filariasis in Papua New GuineaLink to ProtocolFirst Principal InvestigatorWeil, Gary Disease/Disease AreaFilariasis Site CountriesPapua New Guinea Source of Protocolclinicaltrials.gov Approximate Page Count90 Date of Scientific Journal Publication6/26/2019 Scientific Journal Publicationhttps://pubmed.ncbi.nlm.nih.gov/31233507/ |
Filariasis | Oceania |
| Foy, Brian |
Repeat ivermectin mass drug administrations for control of malaria: a pilot safety and efficacy studyLink to ProtocolFirst Principal InvestigatorFoy, Brian Disease/Disease AreaMalaria Site CountriesBurkina Faso Source of Protocolclinicaltrials.gov Approximate Page Count58 Date of Scientific Journal Publication3/13/2019 Scientific Journal Publicationhttps://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32321-3/fulltext |
Malaria | Africa |
| Hatherill, Mark |
A Randomized, Placebo Controlled, Partially Blinded Phase II Study to Evaluate Safety, Immunogenicity, and Prevention of Infection with Mycobacterium tuberculosis of AERAS-404 and BCG Revaccination in Healthy AdolescentsLink to ProtocolFirst Principal InvestigatorHatherill, Mark Disease/Disease AreaTuberculosis Site CountriesSouth Africa Source of ProtocolNEJM Approximate Page Count363 Date of Scientific Journal Publication7/12/2018 Scientific Journal Publicationhttps://www.nejm.org/doi/full/10.1056/NEJMoa1714021 |
Tuberculosis | Africa |
| Morillo, Carlos |
A randomized double-blind placebo-controlled trial of benznidazole in patients with chronic Chagas’ heart diseaseLink to ProtocolFirst Principal InvestigatorMorillo, Carlos Disease/Disease AreaChagas Site CountriesBrazil Source of ProtocolNEJM Approximate Page Count74 Date of Scientific Journal Publication10/1/2015 Scientific Journal Publicationhttps://www.nejm.org/doi/full/10.1056/nejmoa1507574 |
Chagas | South America |
| Roth, Daniel |
Randomized placebo-controlled trial of maternal vitamin D supplementation during pregnancy and lactation to improve infant linear growth in Dhaka, BangladeshLink to ProtocolFirst Principal InvestigatorRoth, Daniel Disease/Disease AreaStunting Site CountriesBangladesh Source of ProtocolNEJM Approximate Page Count192 Date of Scientific Journal Publication8/9/2018 Scientific Journal Publicationhttps://www.nejm.org/doi/full/10.1056/NEJMoa1800927 |
Stunting | Asia |
| Hansen, Anne |
Electricity-free Infant Warmer for Newborn ThermoregulationLink to ProtocolFirst Principal InvestigatorHansen, Anne Disease/Disease AreaHypothermia Site CountriesRwanda Source of ProtocolClinicaltrials.gov Approximate Page Count56 Date of Scientific Journal Publication12/21/2018 Scientific Journal Publicationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361488/ |
Hypothermia | Africa |
| Sancovski, Mauro |
A Post-marketing, Observational, Retrospective Study to Assess the Safety of RefortrixTM (Tdap) When Administered During Pregnancy in a Maternal Immunization Program in Brazil.Link to ProtocolFirst Principal InvestigatorSancovski, Mauro Disease/Disease AreaTdap Sub AreaMAT Site CountriesBrazil Source of ProtocolClinicaltrials.gov Approximate Page Count80 Date of Scientific Journal Publication6/20/2019 Scientific Journal Publicationhttps://pubmed.ncbi.nlm.nih.gov/31216218/ |
Tdap | South America |
| Dorsey, Grant |
Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and Infants First Principal InvestigatorDorsey, Grant Disease/Disease AreaMalaria Site CountriesUganda Source of Protocolclinicaltrials.gov Approximate Page Count93 Date of Scientific Journal Publication7/17/2018 Scientific Journal Publicationhttps://pubmed.ncbi.nlm.nih.gov/30016328/ |
Malaria | Africa |
| Dawson, Rodney |
A Phase 2 Open‐Label Partially Randomized Trial to Evaluate the Efficacy, Safety and Tolerability of combinations of bedaquiline, moxifloxacin, PA‐824 and pyrazinamide during 8
weeks of treatment in Adult Subjects with Newly Diagnosed Drug‐Sensitive or Multi Drug‐
Resistant, Smear‐Positive Pulmonary Tuberculosis. First Principal InvestigatorDawson, Rodney Disease/Disease AreaTuberculosis Site CountriesSouth Africa, Tanzania, Uganda Source of Protocolclinicaltrials.gov Approximate Page Count112 Date of Scientific Journal Publication12/7/2019 Scientific Journal Publicationhttps://pubmed.ncbi.nlm.nih.gov/31732485/ |
Tuberculosis | Africa |
| Raqib, Rubhana |
A Phase 1 Randomized, Double-Blinded, Placebo-controlled, Dose-Escalation Study to Assess the Safety, Tolerability and Immunogenicity of Live Attenuated, Oral Shigella WRSS1 Vaccine in Bangladeshi ToddlersLink to ProtocolFirst Principal InvestigatorRaqib, Rubhana Disease/Disease AreaShigellosis Site CountriesBangladesh Source of Protocolclinicaltrials.gov Approximate Page Count64 Date of Scientific Journal Publication3/19/2019 Scientific Journal Publicationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663145/ |
Shigellosis | Asia |
| Alirol, Emile |
A randomized, double blind, clinical trial of two dose regimens of VINS polyvalent antivenom for the treatment of snake bite with neurotoxic envenomingLink to ProtocolFirst Principal InvestigatorAlirol, Emile Disease/Disease AreaEnvenoming Site CountriesNepal Source of ProtocolPI Email Approximate Page Count58 Date of Scientific Journal Publication5/16/2017 Scientific Journal Publicationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446183/ |
Envenoming | Asia |
| Herrera Valencia, Socrates |
Phase 1 and 2a Clinical Trial: Immunization of human volunteers with P. vivax irradiated sporozoitesLink to ProtocolFirst Principal InvestigatorHerrera Valencia, Socrates Disease/Disease AreaMalaria Site CountriesColombia Source of ProtocolPLOS Approximate Page Count61 Date of Scientific Journal Publication11/19/2016 Scientific Journal Publicationhttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005070 |
Malaria | South America |
| Robb, Merlin |
HIV-1 Prevalence, Incidence, Cohort Retention, and Host Genetics and
Viral Diversity in Cohorts in
East Africa and ThailandLink to ProtocolFirst Principal InvestigatorRobb, Merlin Disease/Disease Area Site CountriesThailand Source of ProtocolNEJM Approximate Page Count450 Date of Scientific Journal Publication6/2/2016 Scientific Journal Publicationhttps://www.nejm.org/doi/full/10.1056/NEJMoa1508952 |
Asia |
Downloadable Clinical Trial Protocol Registry
Download the Clinical Trial Protocol Registry to access a detailed Excel spreadsheet of all the publicly available global health protocols included in the Protocol Library and the links to access them.
Protocol Library
The Protocol Library includes publicly available global health trial protocols (sorted into disease area folders).
Please note: Implementors of studies should also always refer to relevant regulatory standards and guidelines (e.g. FDA, EMA) to assist with study/protocol design.
